Jeremy Cluff|Arizona Republic
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Week 5 of the 2021 NFL season could provide a lot of fireworks on the playing field.
The Los Angeles Rams and Seattle Seahawks kick off the weekon Thursday Night Football on Oct. 7.
The Green Bay Packers vs. Cincinnati Bengals, Cleveland Browns vs. Los Angeles Chargers, San Francisco 49ers vs. Arizona Cardinals and Buffalo Bills vs. Kansas City Chiefs are among the many intriguing games on Sunday, Oct. 10.
The Indianapolis Colts and Baltimore Ravens wrap up the week on Monday Night Football on Oct. 11.
Check out the complete Week 5 NFL schedule for the 2021 season below. All times MST.Click on each game for picks and predictions.
NFL Week 5 picks, predictions:
- Rams vs. Seahawks | Jets vs. Falcons | Saints vs. Washington
- Packers vs. Bengals | Patriots vs. Texans | Dolphins vs. Bucs
- Lions vs. Vikings | Broncos vs. Steelers | Eagles vs. Panthers
- Titans vs. Jaguars | Browns vs. Chargers | Bears vs. Raiders
- 49ers vs. Cardinals | Giants vs. Cowboys | Bills vs. Chiefs
- Colts vs. Ravens | NFL Week 5: Schedule/TV | Odds, lines
- The Republic's Week 5 picks/predictions | Power rankings
Thursday Night Football
Los Angeles Rams at Seattle Seahawks, 5:20 p.m., Fox, NFL Network
This NFCWest rivalry takes center stage in Week 5 and it is an important game. The Seahawks, at 2-2, don't want to fall further back in the division race.
More: NFL power rankings: Arizona Cardinals best team after Week 4 win over Los Angeles Rams
Sunday very early game
New York Jets at Atlanta Falcons, 6:30 a.m., NFL Network
Zach Wilson looked much improved in his team's win over the Tennessee Titans in Week 4. Can he lead the Jets to a win over the Falcons in Week 5?
Sunday early games
Detroit Lions at Minnesota Vikings, 10 a.m., Fox
The Vikings are just 1-3 on the season and the Lions are 0-4. Still, this NFC North game is always worth keeping an eye on.
New Orleans Saints at Washington Football Team, 10 a.m., CBS
The Saints, at 2-2, can't afford to lose this game if they want to stay close to the Tampa Bay Buccaneers and Carolina Panthers in the NFC South.
New England Patriots at Houston Texans, 10 a.m., CBS
The Patriots are much better than their 1-3 record, at least we think they are. A win over the Texans would help New England considerably.
Miami Dolphins at Tampa Bay Buccaneers, 10 a.m., CBS
A win is a win and while their victory over the Patriots wasn't pretty, it still counts for the Buccaneers. They shouldn't have any problems with the Dolphins, right?
Green Bay Packers at Cincinnati Bengals, 10 a.m., Fox
The Packers have looked good after a very rough first game of the season. Can Aaron Rodgers and company win their fourth game in a row against a much-improved Bengals team?
Denver Broncos at Pittsburgh Steelers, 10 a.m., Fox
The quarterbacks will play a huge role in this game, as they do in most NFL games, but will it be Teddy Bridgewater or Drew Lock for the Broncos?
Philadelphia Eagles at Carolina Panthers, 10 a.m., Fox
This game has us very intrigued. Will the Panthers rebound from their first loss or will Jalen Hurts and the Eagles bring them back to earth even more after Carolina's 3-0 start?
Tennessee Titans at Jacksonville Jaguars, 10 a.m., CBS
The Titans should win this game, but we thought they should beat the Jets in Week 4 as well. Tennessee has some big issues on defense and it could use Julio Jones and A.J. Brown back on offense.
More: NFL Week 5 odds: Money lines, point spreads, over/under for every Week 5 NFL game
Sunday late games
Cleveland Browns at Los Angeles Chargers, 1:05 p.m., CBS
The Browns have quietly compiled a 3-1 record, but have some tough games ahead. Their defense has impressed, but can it contain Justin Herbert and the Chargers?
Chicago Bears at Las Vegas Raiders, 1:05 p.m., CBS
Justin Fields looked so much better in Week 4 than he did in Week 3, but the Raiders provide a much bigger test than the Lions.
San Francisco 49ers at Arizona Cardinals, 1:25 p.m., Fox
The Cardinals are surprisingly 4-0 and on top of the NFC West. A win over the 2-2 49ers would certainly help their cause in the division.
New York Giants at Dallas Cowboys, 1:25 p.m., Fox
The Cowboys have won three straight games after losing in Week 1 to the Buccaneers. The Giants are coming off a win and got some much-needed confidence, so this game might get interesting.
More: NFL Week 5 picks, predictions from The Arizona Republic
Sunday Night Football
Buffalo Bills at Kansas City Chiefs, 5:20 p.m., NBC
A possible AFC Championship Game preview? Both of these teams have high-flying, explosive offenses, so this game might come down to a stop on defense. Get your popcorn ready.
Monday Night Football
Indianapolis Colts at Baltimore Ravens, 5:15 p.m., ESPN
Just when we were ready to write off the Colts, they got their first win of the season. Getting their second in Baltimore in Week 5 will not be an easy task.
Highest paid NFL players:
- Quarterbacks|Running backs|Wide receivers|Tight ends
- Cornerbacks|Safeties|Linebackers|O-linemen|D-linemen
- Edge rushers|Highest paid players: Overall|By position
Reach Jeremy Cluffat jeremy.cluff@arizonarepublic.com.Follow him on Twitter @Jeremy_Cluff.
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